Tau (PHF-1) | ALZFORUM
Feb 5, 2024 · PHF-1 reacts with tau phosphorylated at serine-396 and serine-404. Western blot of recombinant human tau phosphorylated in vitro with GSK3β, probed with PHF-1. WT, wild …
ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
Feb 1, 2025 · To find out, the scientists turned to surface plasmon resonance, a technique that quantifies molecular interactions in real time. It showed that ApoE3Ch clings onto tau …
Better Diagnosis with Blood Test Detecting Only Tau Made in Brain
Dec 29, 2022 · In the December 27 Brain, Karikari reported that plasma concentration of these brain-derived forms of tau (BD-tau) tracked with cerebrospinal fluid markers of amyloid …
Cell-Based Assay Matches Tau Strains to Neuropathological …
Jan 30, 2025 · Tau, Incorporated. A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril strains. …
LY3954068 | ALZFORUM
Nov 25, 2024 · LY3954068 is a small interfering RNA (siRNA) that targets expression of the microtubule-associated binding protein tau. No information is available about the makeup of …
After Tau Immunotherapy, Tangle Markers Tank in CSF, Plasma
Dec 24, 2025 · In a small, open-label trial in people with mild to moderate, dominantly inherited Alzheimer’s disease (DIAD), the tau immunotherapy etalanetug almost abolished markers of …
Tau (CP-13) - ALZFORUM
Feb 7, 2024 · This monoclonal antibody, generated against paired helical filaments (PHFs) isolated from Alzheimer’s brains, recognizes tau phosphorylated at serine 202. Recognizes tau …
JNJ-64042056 | ALZFORUM
In both wild-type C57BL/6 and P301L mutant tau transgenic mice, a three-month regimen of subcutaneous ACI-35 injection rapidly generated high titers of polyclonal IgG antibodies …
Tau (MC-1) - ALZFORUM
Feb 6, 2024 · The interaction of MC-1 with recombinant tau suggests that post-translational modifications are not required to generate the MC-1 epitope. However, it remains possible that …
BMS-986446 | ALZFORUM
Feb 1, 2023 · Secondary outcomes include brain tau deposition as per PET, the iADRS, ADASCog14, and ADCS-iADL measures of cognition and function, plus the MMSE. The trial, …