In living cells, regulation of the electrochemical environment is supposed to be managed by ion channels—protein complexes that reside in cell membranes and assume definite shapes. So, it’s surprising ...

TDP-43 leads a varied life, interacting with a host of different RNAs and proteins as it shuttles from the nucleus to the cytoplasm and back. This offers this RNA-binding protein plenty of ...

New findings provide details about the hidden organization of the cytoplasm, showing it makes a big difference where in that cellular broth that messenger RNA (mRNA) get translated into proteins. The ...

Forty years ago, a postdoctoral researcher named James McGrath who would go on to spend more than three decades as a clinical geneticist and research scientist at Yale, made a discovery that advanced ...

Back in 2018, the lab of Christine Mayr, MD, PhD, at Memorial Sloan Kettering Cancer Center (MSK) introduced the world to a key cellular component that had been hiding in plain sight. Now the lab is ...

It’s a familiar image, reprinted in countless biology textbooks: an illustration of a typical cell, halved like a grapefruit to reveal its innards. Strands of endoplasmic reticulum encircle a nucleus ...