Researchers used advanced imaging to uncover early molecular changes in bone that may enable earlier diagnosis of osteoarthritis CHENGDU, SICHUAN, CHINA, February 10 ...

Osteoarthritis (OA) represents the most prevalent form of chronic degenerative joint disease worldwide. The dynamic interplay between cartilage and subchondral bone is essential for preserving joint ...

Osteoarthritis often goes undetected until cartilage damage is advanced, limiting treatment options. A new study shows that molecular changes in subchondral bone occur earlier and can signal disease ...

Menopause is one risk factor for osteoarthritis. One recent study in mice uncovered that menopause led to a drop in 17beta-estradiol and progesterone, which increased cartilage aging, degeneration, ...

Spatial MALDI-MSI of osteoarthritic knee joints reveals bone-derived protein signatures linked to disease progression. These candidates will be validated in larger patient cohorts and OA mouse models ...