Figure 1: Overall structure of the GCGR–NNC0640–mAb1 complex. Figure 2: Ligand-binding mode of GCGR to NNC0640. Figure 3: Stalk and ECL1 in the full-length GCGR structure. The importance of the ...
Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases, such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length class B receptor, ...
Lipid kinases are among the promising targets of new classes of drugs, due mainly to class I PI3Kα, which plays a crucial role in carcinogenesis and metastasis. This enzyme is hyperactive in 30-40% of ...
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