Chemotherapy kills cancer cells, but it also leaves behind something troubling: damaged cells that stop dividing yet refuse ...

Senescent cells walk a tightrope, risking cell death with high levels of iron and other damaging agents, but compensating for this by overproducing a protective protein, GPX4, which staves off death.

Figure 6. Senescent heterogeneity model based on DNA content. Compared to G1-arrested cells, G2-arrested senescent cells express higher levels of senescence-associated markers, secrete more IL-6, and ...

A new set of drugs exploit a recently-revealed weakness in 'zombie-like' – or senescent – cells that could lead to new ...

“Our results offer ‘proof of concept’ for the future use of a pharmaceutical senolytic strategy to reduce the risk of IR-induced GI cancer.” “Our results offer ‘proof of concept’ for the future use of ...

PRESS RELEASENew Preclinical Data on STX-1, a First-in-Class Senolytic ADC, To Be Presented at AACR 2026Presentations highlight therapy-induced ...

Scientists are developing therapies to eliminate chemotherapy-induced senescent 'zombie' cells, which may fuel inflammation and cancer relapse. These approaches include repurposing existing cancer ...

Researchers at The University of Texas Health Science Center at San Antonio have discovered a way to delay or even block recurrence of the deadliest brain cancer after radiation, bringing new hope for ...