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The way proteins move is often what gives them biological activity: they can open, close, twist, and rearrange themselves in ways that allow them to bind to other molecules or perform complex ...

Jia’s team developed a protocol to improve the screening of protein pockets. This involved identifying the pockets, removing ...

Protein design is crucial for the treatment of human diseases, but traditional protein design methods have some limitations. Site-directed mutagenesis is highly dependent on the physiological ...

In 2023, scientists in the joint School of Engineering and School of Life Sciences Laboratory of Protein Design and Immunoengineering (LPDI), led by Bruno Correia, published in Nature a deep-learning ...

Researchers from the University of Science and Technology of China (USTC), led by Prof. Liu Qi, in collaboration with Harvard Medical School's Marinka Zitnik lab, have developed a novel deep ...

COMET, a novel machine learning framework, integrates EHR data and omics analyses using transfer learning, significantly enhancing predictive modeling and uncovering biological insights from small ...

WEST LAFAYETTE, Ind. – Proteins are often called the working molecules of the human body. A typical body has more than 20,000 different types of proteins, each of which are involved in many functions ...

Scientists have used deep learning to design new proteins that bind to complexes involving other small molecules like hormones or drugs, opening up a world of possibilities in the computational design ...