USP7 deubiquitinates and stabilizes not only p53, but also Mdm2, the primary E3 ubiquitin ligase of p53. 16, 17 Given that both p53 and Mdm2 are known regulators of the steady-state level of PolĪ·, we ...
DNA polymerase eta (polĪ·) belongs to the Y family of specialized DNA polymerases, best characterized for their capacity to replicate DNA damages that block the progression of replicative DNA ...
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