Influence of single agent gemcitabine (GEM) schedule on the pattern of response and toxicity in patients with advanced pancreas, lung and breast carcinoma: A systematic review No significant financial ...
To find an appropriate dose regimen of the novel antibacterial agent antofloxacin for a phase II clinical trial using a population pharmacokinetic (PPK) study in healthy volunteers and the minimum ...
In this video from the 2015 HPC Advisory Council Switzerland Conference, Nishant Kumar Agrawal from Tata Consultancy Services presents: Parallel Implementation of PK-PD Parameter Estimation on Xeon ...
Combined therapy of EGFR TKI and VEGFR TKI may produce a greater therapeutic benefit and overcome EGFR TKI-induced resistance. However, a previous study shows that a combination of EGFR TKI erlotinib ...
Results of a Phase 2 PK/PD study of Oral PTH (1-34) in patients with hypoparathyroidism were presented at the American Society for Bone and Mineral Research Annual Meeting Data suggest favorable ...
Among a small cohort of healthy Korean male volunteers, evogliptin combined with empagliflozin or dapagliflozin had no significant effects on the pharmacokinetics (PK) of each drug. In healthy male ...
PK/PD modeling is essential for understanding ADMET properties, optimizing dosing regimens, and reducing late-stage attrition rates in drug development. AI/ML algorithms enhance PK/PD modeling by ...
Advanced Strategies to Study Plasma Protein Binding, Improve PK/PD, and Develop Better Enzyme Inhibitors In early drug discovery, the molecular hits generated from a high throughput screen (HTS) are ...
Final report of phase I clinical, pharmacokinetic (PK), pharmacodynamic (PD) study of PF-00562271 targeting focal adhesion kinase (FAK) in patients (pts) with solid tumors. A phase I dose-escalation ...
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