A 91-year-old man with a history of bladder carcinoma and left total knee arthroplasty was evaluated because of left knee pain. A culture of synovial fluid showed no growth. A diagnosis was made.

A 91-year-old man was admitted to the hospital with weight loss, dyspnea, and eosinophilia. An anteroposterior chest radiograph obtained 2 months earlier showed bibasilar patchy opacities. A ...

This Sounding Board announces a new FDA policy that the default requirement for FDA approvals will be one robust pivotal trial plus confirmatory evidence, rather than two trials.

The March 2026 issue of NEJM Catalyst Innovations in Care Delivery is a special theme issue on the hard work of implementing artificial intelligence in real-world ...

A 7-year-old boy was brought to a hospital with a 3-month history of cognitive deterioration and seizures. He had contracted measles at 7 months of age while living in an area where the ...

A survey of the NEJM Catalyst Insights Council finds that health care leaders are exploring many uses of artificial ...

When a physician’s own incidental finding sends her down a long and winding path to find answers, she finds herself overcome with worry — but also, eventually, a new appreciation for life.

Early approaches to restricting abortion access, directed mainly at patients (the demand side of the market), had relatively little impact on national abortion rates. So abortion opponents have turned ...

In the management of breast cancer, treatment approaches are locoregional (i.e., surgery and radiotherapy) or systemic (i.e., chemotherapy, targeted therapy, endocrine therapy, and immunotherapy). The ...

Abstract Huge improvements in the treatment of many serious diseases have been made in the past half century, during which I have had the privilege of working first as a pediatric oncologist and later ...

A key barrier to effective government oversight and optimal allocation of health care resources is the use of “related-party transactions” between health care organizations and affiliated entities.

A 62-year-old woman who reported dysgeusia was found to have a serum sodium level of 122 mmol per liter. The serum osmolality was 250 mOsm per kilogram of water, and the urinary osmolality 635 mOsm ...