Stability in the thermal, chemical, and mechanical domains are critical for proper development and delivery of therapeutic proteins. Proteins are frequently exposed to stress throughout purification, ...

Inhibition of aggregation of insulin solution. i) before heating, ii) after heating without PSPB and iii) after heating with PSPB. It can be seen that heating causes white turbidity due to aggregation ...

A new study shows that the protein CHIP can regulate the insulin receptor more efficiently alone than in a paired state. In cellular stress situations, CHIP usually appears as a homodimer - an ...

Researchers dissolved human insulin (Sigma I2643) in acidified deionized water to concentrations of 2 mg/mL. After they had dissolved, the pH was adjusted with 0.1 M HCl and 0.1 NaOH to pH 4.3. All ...