GEN

Improving Tuberculosis Vaccines Using Immune CD8+ Lymphocytes and IL-15

Researchers from the University of Pittsburgh Center for Vaccine Research report that innate CD8+ lymphocytes are essential for curbing tuberculosis (TB) the disease. They also discovered that ...
ascopubs.org

Effect of low FGFR3 but high CD8 T cell infiltrated immune micro-environment on treatment response with pembrolizumab in upper tract urothelial carcinoma.

Effect of spatial transcriptomics on tumor immune microenvironment resistant to immune checkpoint inhibitors in metastatic urothelial carcinoma. This is an ASCO Meeting Abstract from the ASCO ...
Kaleido Scope

Boosting the immune defense: interleukin-2 promotes fate decisions in CD8 T cells for long- or short-term immune protection

The immune system is a complex network of cells and proteins with a simple job. Defend the body against infection. To do that, the cells must recognize and destroy infecting viruses or bacteria. In ...
The American Journal of Managed Care

CD4/CD8 Ratio a Useful Predictor of Mortality in Patients Living With HIV

A review found that CD4/CD8 ratio could be used as a prognostic marker for mortality in patients with HIV, though future studies need to be done to confirm these findings. Clinical practices can ...
ascopubs.org

Harnessing transcriptome signatures and CD103+CD8+ immune infiltration for prognosis and treatment outcomes in anal squamous cell carcinoma.

Immunotherapy combined with hypofractionated radiotherapy and chemotherapy for locally recurrent rectal cancer (TORCH-R): A prospective, single-arm, two-cohort, phase II trial. This is an ASCO Meeting ...
BioWorld

Mozart Therapeutics’ bispecific CD8 Treg modulator does not increase unwanted immune cell activation, pro-inflammatory cytokines

Mozart Therapeutics Inc. has reported preclinical pharmacologic and tolerability data for MTX-101, a bispecific CD8 regulatory T-cell (Treg) modulator targeting inhibitory KIR2DL(1/2/3) and CD8 ...