In vitro maturation (IVM) refers to the culture of immature human oocytes to the metaphase II stage outside the body, offering an alternative to conventional stimulated cycles. Typically, oocytes are ...

The cumulus-oocyte complex (COC) represents a critical unit within the ovarian follicle that mediates oocyte maturation, ovulation and subsequent fertilisation. Dynamic interactions between the oocyte ...

Human oocytes can last for up to 50 years—and a newly discovered metabolic pathway is key to this longevity. By Lauren J. Young Published Jul 22, 2022 2:45 PM EDT Add Popular Science (opens in a new ...

Mechanistic model for MTOC maturation in GV oocytes. The MTOC (grey) activates near the oocyte cortex, which requires recruitment of CKAP5 and TACC3. After activation, MTOC migrates to the nuclear ...

DLGAP5 is proposed as a causal gene related to oocyte meiosis disorder for the first time. It expanded the current spectrum of pathogenic genes responsible for the phenotype of oocyte maturation and ...