In dementia diseases such as Alzheimer's, incorrectly folded proteins accumulate in the brain. Researchers have now resolved a particularly active species of protein fibrils with unprecedented ...

The accumulation of neurofibrillary tangles is the common thread among all tauopathies, yet each amasses fibrils with a distinct fold at their core. What forces goad tau into twisting into these ...

Researchers have developed a new tool, FibrilPaint combined with the FibrilRuler test, that allows scientists to directly measure the length of toxic Tau amyloid fibrils in tiny fluid samples, from ...

A new imaging technique developed by engineers at Washington University in St. Louis can give scientists a much closer look at fibril assemblies, stacks of peptides like amyloid beta, most notably ...

A new imaging technique developed by engineers at Washington University in St. Louis can give scientists a much closer look at fibril assemblies, stacks of peptides like amyloid beta, most notably ...

Some call them soluble oligomers, others prefer the term protofibrils. Regardless, most researchers agree on two things when it comes to free-wheeling aggregates of Aβ: They are more toxic than their ...