Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.

EMBL researchers created SDR-seq, a next-generation tool that decodes both DNA and RNA from the same cell. It finally opens access to non-coding regions, where most disease-associated genetic variants ...

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark ...

The expression of genes has to be very carefully controlled by cells; serious problems can arise when genes are expressed in the wrong places, at the wrong times, or at the wrong levels, for some ...

What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too large or too small are linked to many diseases. Until now, the genetic basis ...

When a gene produces too much protein, it can have devastating consequences on brain development and function. Patients with an overproduction of protein from the chromodomain helicase DNA binding ...