SUMMARY At the leading edge of a polarized macrophage, a membrane-based chemotaxis pathway directs cell mi- gration up attractant gradients to sites of infection, inflammation, or tissue damage. Upon ...

Shc (Src homology 2 domain containing) adaptors are ubiquitous components of the signaling pathways triggered by tyrosine kinase-coupled receptors. In lymphocytes, similar to other cell types, the p52 ...

The intricate mechanisms that allow certain cells to move have been uncovered by researchers, discoveries with implications for cancer metastasis, say authors of a new report. What if cancer cells ...