T cells play a big role in bringing cell and gene therapies to patients. Despite this clinical potential, scientists developing T cell therapies such as chimeric antigen receptor (CAR)-T cells, ...

In January 2024, the FDA updated its guidance on CAR-T therapies, emphasizing the need for enhanced safety and quality measures. This update followed a series of warnings regarding the risk of T cell ...

The most common method for evaluating replication competency of lentivirus and AAV vectors is through serial passaging of virus in cell culture lines and subsequent identification of viral particles ...

Images of human cells at different stages of mitosis. Chromosomes are colored cyan, spindle microtubules in red and spindle poles are yellow. Each day, hundreds of billions of cells in our body cycle ...

Like traditional biologics, cell and gene therapies (CGTs) must meet safety and efficacy standards before they can be administered to human patients. But the manufacturing processes used for this new ...

As basic building blocks of cells, proteins have vital functions in the organism. The instructions for their synthesis are found in the DNA. So that an exact blueprint for each protein can reach the ...

Every year, the media informs us that we’re on the cusp of the golden age of something. While the expected trend often comes to fruition, it’s rarely as smooth a process as advertised. Drug discovery ...

Recent research has shed light on the complex processes that cells use to maintain the quality of mitochondrial DNA (mtDNA) for inheritance across generations. These processes are particularly ...

Glioblastoma remains one of the most challenging solid tumors to treat due to its highly immunosuppressive tumor microenvironment.