When apoptosis is initiated by manganese (II) loading, hyperthermia or thapsigargin treatment, human HL-60 and AsPC-1 cells initiate de novo synthesis of the C5a receptor (C5aR) and generation of its ...
Complement activation can occur through three established pathways: classical, alternative and lectin, resulting in the cleavage of C3 and C5 to generate anaphylatoxin peptides (C3a and C5a) and C3b ...
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